Melatonin and GABA (Gamma-Aminobutyric Acid) Relaxation and immunity.
Melatonin is an attractive pharmacological candidate for aged and immunocompromised individuals. Melatonin plays a critical role in regulating photoperiodic signals and has recently been shown to decrease immunosenescence, which is the gradual deterioration of the immune system brought on by natural aging. The Journal of Biomedical Research concludes that melatonin supplementation may enhance immunity in aged individuals by upregulating immunosenescence indices in association with T lymphocytes.
Melatonin is the most popular natural sleep aid for good reason. Melatonin receives the highest ranking of “A” from the Natural Standard, now Natural Medicines, an independent database that reviews alternative and complementary treatments. Melatonin shows strong evidence for combating jet lag and enhancing the sleep of healthy people. Melatonin receives a “B,” or good evidence for the treatment of insomnia in the elderly, says Natural Medicines.
Melatonin therapy for jet lag. Melatonin is a hormone that signals to the body when it is time for sleep. Travelers may consider taking a melatonin supplement five days before traveling at a time that coincides with evening of their destination. This will help prepare you for the new location’s time difference.
GABA (Gamma-Aminobutyric Acid)
After 60 minutes of administration, GABA significantly increases alpha waves and decreases beta waves compared to water or L-theanine. These findings denote that GABA not only induces relaxation, but also reduces anxiety.
GABA could work effectively as a natural relaxant and its effects could be seen within 1 hour of its administration to induce relaxation and diminish anxiety. Moreover, GABA administration could enhance immunity under stress conditions.
Each patch contains: Melatonin 5mg, GABA Gamma-Aminobutyric Acid 4mg.
Sources: US National Library of Medicine National Institutes of Health – Pharmacological advantages of melatonin in immunosenescence by improving activity of T lymphocytes.
National Center for Biotechnology Information – Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans.