Methylcobalamin is the activated form of vitamin B12. Methylcobalamin has been used to treat B vitamin nutritional deficiencies and other diseases like Alzheimer’s disease and rheumatoid arthritis.
As an auxiliary agent, methylcobalamin exerts neuronal protection by promoting regeneration of injured nerves and antagonizing glutamate-induced neurotoxicity. Recently several lines of evidence demonstrated that Methylcobalamin may have potential analgesic effects in experimental and clinical studies.
For example, methylcobalamin alleviated pain behaviors in diabetic neuropathy, low back pain and neuralgia. Methylcobalamin improved nerve conduction, promoted the regeneration of injured nerves, and inhibited ectopic spontaneous discharges of injured primary sensory neurons.